St. Clairsville is located in east central Ohio along Interstate 70. It is 10 miles from the eastern border of Ohio along the Ohio River. When traveling by automobile, exit Interstate 70 at exit 215 (U.S. 40 intersection) or exit 216 (S.R. 9 intersection).

Port Columbus Airport is approximately a two hour drive west. Pittsburgh International Airport is one and a half hours northeast of St. Clairsville. The drive from either airport is easy, convenient and scenic.

From Columbus:
Take Interstate 70 east directly to St. Clairsville.

From Cleveland:
Take Interstate 71 south to Interstate 70 east to St. Clairsville.
or
Take Interstate 77 south to Interstate 70 east to St. Clairsville.

From Pittsburgh, PA:
Take Interstate 79 south to Interstate 70 west to St. Clairsville.